منابع مشابه
Plasma concentrations and clinical effects of lorazepam after oral administration.
The relation between plasma concentrations and properties of lorazepam administered orally as premedication was studied in patients undergoing minor surgery. The drug was found to be reliably absorbed in most subjects producing plasma concentrations similar to those reported after injection. Effective concentrations were obtained within 30-60 min, maintained for 4-6 h and were closely related t...
متن کاملMeasurement of plasma volume in neonates.
There is no reliable and safe method for measuring plasma volume in ill newborn infants. We describe an adaptation of the dye dilution technique using indocyanine green as the plasma label, which can be used in the sickest and smallest of infants with the minimum of disturbance. To avoid the need to take large volumes of blood from the infant, samples were diluted 1:1 with distilled water and p...
متن کاملA study of the plasma concentrations of lorazepam in mother and neonate.
A standard dose of lorazepam 2.5 mg was given i.v. to two groups of mothers: (a) before surgical induction of labour and (b) at the beginning of the second stage of labour. A group of non-pregnant women was studied as control. Plasma concentrations of lorazepam were measured by gas-liquid chromatography, in the mothers before delivery, and in the mother and neonate at delivery and 24 and 48 h t...
متن کاملAntipyrine, indocyanine green, and lorazepam determined in plasma by high-pressure liquid chromatography.
This HPLC method for measuring antipyrine, lorazepam, and indocyanine green in 0.5 mL of plasma can be used in studies of liver function in which these "model" compounds are used. After a fast, simple, one-step extraction procedure with acetonitrile, an isocratic HPLC system is used, with a single detection wavelength (214 nm) and a single internal standard (1-acetamidopyrene). The mobile phase...
متن کاملBispectral index values, sedation-agitation scores, and plasma Lorazepam concentrations in critically ill surgical patients.
BACKGROUND Publications on the use of the bispectral index for sedation monitoring in the intensive care unit are increasing. However, few studies have involved correlation of bispectral index with serum drug concentrations. OBJECTIVES To assess the degree of correlation between bispectral index values, scores on the Sedation-Agitation Scale, and steady-state serum concentrations of lorazepam...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1978
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1978.tb08376.x